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Given that ASD is a highly prevalent and serious neurodevelopmental disorder that constitutes a substantial burden on individuals, families, and society, educators face a growing demand for quality instruction that benefits students with ASD. In this context, computer science education, in particular, is a discipline to which scholars have paid little attention. Motivated by this gap in the research, we examined the impact of computing instruction in an online, flipped environment on the acquisition of computing concepts and student engagement. In addition, we investigated the challenges that arose due to instructional design and materials. We discuss findings from this study and provide specific implications for research and instructional design.