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This longitudinal study examined the predictive validity of bilingual language proficiency, decoding, and oral reading fluency (ORF) skills in Spanish and English to predict reading comprehension (RC) within and across languages. Participants were 600 native Spanish-speaking students enrolled in Spanish/English bilingual programs in first and second grade. Results indicated (a) that bilingual language proficiency significantly predicted English and Spanish RC, (b) English and Spanish decoding gains in first grade significantly predicted English RC at the end of second grade, (c) English ORF initial status and gain and Spanish ORF gains significantly predicted English RC at the end of second grade, and (d) Spanish ORF initial status, and bilingual language proficiency significantly predicted Spanish RC at the end of second grade.