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The present study investigated the effect of morpho-phonemic analysis instruction on the acquisition of meanings and spellings of morphologically complex academic words. Employing a within-subject design, 30 fourth- and fifth-grade Spanish-English bilingual students were taught two sets of derivational words of various orthographic and phonological opaqueness under morpho-phonemic analysis (treatment) and whole word (control) conditions. Positive treatment effects were observed for both meaning and spelling outcomes. Further analyses on spelling performance revealed larger treatment benefits on affix and word-level spelling compared to base spelling. Findings from our study show the promise of morpho-phonemic analysis instruction for teaching complex academic words among upper-elementary bilingual students.