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This study explores the relationship between first-generation status, research self-efficacy, academic locus of control, and research outcome expectancy in undergraduates during early research experiences. Three instruments related to research self-efficacy were administered to third- and fourth-year first-generation (n = 87) and non-first-generation (n = 109) undergraduate social science students at a research university in the southeastern united states. Results of a multiple linear regression suggest that research outcome expectancy scores and academic locus of control scores predicted overall research self-efficacy scores. Results were generally consistent across subscales. First-generation status did not predict overall research self-efficacy but did moderate the strength of the relationship between research outcome expectancy and overall research self-efficacy. Implications are discussed.