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This study uses a nationally representative dataset to disaggregate the influence of DE course-taking (i.e., participation, subject area of DE credits, number of DE credits) on students’ STEM major selection in college, particularly for the historically underrepresented students in STEM. We find that taking DE courses is positively associated with an increased probability of majoring in STEM, especially at the baccalaureate level. No significant relationship was detected between DE in Math/Science and STEM major choice, and the probability of majoring in STEM with fewer DE credits is not more or less sensitive to DE credits than those with more DE credits.