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Effective evidence-based interventions that target students’ motivation and basic psychological needs are critical. However, most education interventions focus on students’ cognitive abilities and test scores. Self-determination Theory (SDT) has been adopted in education for more than two decades to provide valuable insights into students’ motivation and basic psychological needs. This systematic review included 51 SDT-based intervention studies (n = 14,285 participants), which provided a comprehensive profile (i.e., study design, sample size, students’ age, subject, country, primary dependent variables, and intervention results). Specifically, teacher-oriented, student-oriented, parent-oriented, and mentor-mentee intervention approaches were discussed. The findings of this study provided evidence for researchers and practitioners to understand how to conduct subject, age, culturally, and diversity-sensitive interventions in the future.