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Pre-service education and in-service teacher professional development (collectively termed “TPD”) opportunities in low- and middle-income countries (LMICs) are often limited, unsustained, and not evidence-based. Educational technologies offer significant potential to enhance. We present the first systematic literature review characterising culturally appropriate and effective uses of technology in TPD in LMICs. An in-depth synthesis of 170 studies spanning 40 countries considered macro-, meso- and micro-level factors in TPD design and implementation. The analysis included global teacher survey data and ongoing initiatives in LMICs. Results showed benefits for teachers, but evidence for sustainability, cost-effectiveness or tangible impacts on classroom practice and student outcomes was thin, alongside limited attention to marginalised groups. Recommendations are made for researchers, policymakers, teachers and teacher educators.