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We examined the influence of (a) technological, pedagogical, content knowledge (TPACK) domains, (b) Self-Efficacy (SEFF), and (c) Tondeur et al.’s (2016) SQD model, which assessed teacher candidates’ opportunities to integrate technology into their pre-professional teaching experiences on their intentions to integrate technology into instruction. Results from a structural equation model indicated TPACK influenced SQD and SEFF; and SQD and SEFF influenced intention to teach with technology. The final model accounted for 65.5% of the variance. In this work, we added several layers of complexity to prior research by developing and assessing a comprehensive model of the influence of TPACK knowledge domains, self-efficacy, and SQD-measured opportunities to engage with technology for instruction on technology integration. Implications for practice were also discussed.