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The current study used an intersectional within-group approach (skin tone and gender identity) to assess the mediating influence of race-related stress in explaining Black college students’ depression, anxiety, stress, and GPA. We sampled 322 Black college students (n = 232 Dark Skin; 71.7 % Female; 56.7% 1st & 2nd year) to deploy an intra-categorical intersectional descriptive analytic approach, using ANOVA and multivariate linear regression techniques. Results suggest gender variation in anxiety and stress, with all three race-related stresses mediating this relationship. There was also skin-tone variation in stress, with cultural and institutional race-related stressors mediating this relationship. Implications for future research are discussed.