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The Sensitivity of Multisite Designs to the Misspecification of the Treatment Heterogeneity Parameter (Poster 9)

Thu, April 13, 4:40 to 6:10pm CDT (4:40 to 6:10pm CDT), Hyatt Regency Chicago, Floor: East Tower - Exhibit Level, Riverside West Exhibition Hall

Abstract

A central challenge in designing an effective and efficient multisite trial is that the documentation of the novel design parameter— site-by-treatment variance — is lacking. Thus, the design efficiency and power potentially diminish because of the misspecification of this design parameter. In this study, we examine the impact of misspecifying the treatment heterogeneity parameter — the site-by-treatment variance — on the power and optimal sampling plans for multisite cluster randomized trials.

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