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International collaboration is a well-known strategy for university research capacity building, particularly in developing countries from the so-called “Global South.” Thus, building research networks with countries that have developed research systems, most in the “Global North,” is vital. However, there is little evidence about how collaboration emerges and which strategies are the most successful for universities in the Global South. This proposal addresses this issue by comparing the cases of five Chilean universities with emerging research capacities. Data were drawn from 40 interviews with top administrators and bibliometrics. Across the sample, we found stronger links to the United States and European institutions. Nevertheless, we highlight the case of one university that exhibited an intense form of South-to-South collaboration.