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This study adds to the growing body of research employing rigorous estimation methodologies to understand the effectiveness of CTE programming for postsecondary education outcomes. We use a regression discontinuity approach to measure the effect of CTE Center enrollment on college enrollment, type of college enrollment (2-year or 4-year), and enrollment persistence. The study leverages data for five high school student cohorts in a large urban district where seats in selective admissions CTE Centers are assigned using a deferred-acceptance algorithm based on a composite score of achievement measures from middle school. The results demonstrate that CTE has a negative effect on college enrollment and no impact on type of institution enrolled. Results for college persistence will also be discussed.