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This study explores the relationship between students’ perceived norms and attitudes toward sexual behaviors, self-efficacy to refuse intercourse behaviors, and achievement goal orientations in sexual health education classrooms. We conducted a profile analysis combined with a mediation modeling to identify five distinct profiles based on students attitudes and perceived peer norms. The results indicate students with more positive attitudes and perceived peer norms are more likely to develop higher self-efficacy to refuse intercourse behaviors in various scenarios. Furthermore, the findings reveal that a mastery goal function as a mediator of the relation of identified student profiles and refusal self-efficacy. Our findings underscore that different attitudes and perceptions of peer norms plays a significant role in shaping students’ refusal self-efficacy.