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This study explored the mediation relationship among stress, insecure attachment (attachment avoidance/attachment anxiety), and avoidance coping. In addition, the study explored meaningfulness and social support-seeking as moderators that intervened the mediation relationship. The moderators’ impact on the direct influence from stress to avoidance was also examined. Participants were 250 college students in the U.S. Hayes’s (2018) PROCESS macro in SPSS was applied to test the mediation and moderated mediation models in the study. Results showed that the mediation relationship was significant. In addition, meaningfulness could intervene stress’s influence on attachment anxiety and stress’s influence on avoidance. Social support-seeking could only intervene attachment anxiety’s influence on avoidance. Findings have practical implications.