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Students with learning disabilities (SWLDs) and women continue to be underrepresented in STEM despite their abilities to succeed and add much-needed diversity of perspective to the field. In this study, we use the 2009 High School Longitudinal Study to explore how 9th grade math self-efficacy and science self-efficacy relate to STEM achievement, as measured by GPA, for SWLDs in high school. Results from regression analyses indicate a significant relationship between 9th grade math self-efficacy and STEM achievement but not science self-efficacy. Further, growth in both self-efficacy measures between 9th and 11th grade relates significantly with end-of-high-school STEM achievement. There are no differential relationships across genders. Policy implications are discussed.