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The goal of systematic reviews is to synthesize existing research to answer research questions. Systematic reviews are comprised of two steps: 1) screen potentially relevant article abstracts and 2) screen the full text of those relevant abstracts for full relevance. With the increasing number of publications, systematic reviews are more time-, labor-, and cost-intensive. Therefore, researchers have developed machine learning-aided programs to help with the first step. ASReview LAB (van de Schoot et al., 2021) utilizes machine and active learning to screen article titles and/or abstracts for relevance. A simulation study is conducted to determine the optimal training data and settings’ combinations to best achieve the ideal recovery of relevant articles using ASReview LAB compared to traditional manual reviews.