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Past studies of the relation between teacher-child relationships (TCRs) and children’ social-emotional skills (SESs) yielded mixed results, so this study determined the link between TCRs and SESs, along with their moderators. This meta-analysis of 68 independent effect sizes in 21 empirical studies of 73,372 children showed strong links between TCRs and SESs. There is a significant positive correlation between the positive TCRs and children's SESs, and a significant negative correlation between negative TCRs and children's SESs. Moreover, students’ culture, age, SESs reporter and SESs type moderated these effects. These results suggest the value of improving teacher-child relationships in policies and practices.