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Sound clinical reasoning, while essential for optimal patient care, can be quite an elusive process. Clinicians may not always be aware of their reasoning process, which may not be obvious to an outside observer either. This study explored the use of electroencephalography (EEG) to examine neurocognitive correlates of clinical reasoning during a simulated American Board of Anesthesiology style standardized oral exam. Eight novice anesthesiology residents and eight fellows who had recently passed their board exams were included in the study. Although both groups reported similar cognitive load, fellows significantly outperformed novices. Some significant differences were noted between fellows’ and residents’ EEG markers. This pilot study provides preliminary evidence that EEG could offer insights into neurocognitive engagement during clinical reasoning tasks.