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This study attends to the lack of research examining the role of the Minority Serving Institution (MSI) context in shaping science identity and how students studying STEM-related fields navigate multiple social identities. HBCU and HSI undergraduate STEM majors completed surveys measuring racial and ethnic identity (REI), racial ethnic self-schemas (RES), and STEM/science identity. Results suggest that while MSI students possess similar RES (e.g., pride in race and nationality) and strong REIs associated with academic achievement, post hoc Tukey HSD analyses, and ANOVA revealed significant differences between participating institutions on the “minoritized” RES in which students are motivated to overcome prejudice to fully engage in society. These analytical findings are presented and posit various hypotheses for measures that merit further study.