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The present study utilized a national representative sample to examine (1) the growth pattern for children’s science achievement from kindergarten to fifth grade; (2) whether learning-related behaviors partially explain the relationships between cognitive function and growth in science after accounting for children individual and school’s characteristics (i.e., age, gender, family SES, race/ethnicity, home language, and school ethnic concentration); and (3) the extent to which the aforementioned relationships vary for classrooms with low-, medium, and high curriculum focus. Results suggested that children’s growth was nonlinear, and their cognitive ability had both direct and indirect effects via learning-related behaviors, and such indirect effects depended on curriculum focus. This study evinced the importance of enhancing children’s science learning by expanded science content areas.