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This study tested elements of Boekarts’ (2011) model of self-regulated learning (SRL) to uncover how undergraduate STEM students’ (N=687) strategies use and goal orientations predicted persistence in their STEM majors. A competing risks survival analysis indicated the probability for any type of major switch was highest in the second year. Higher performance-avoidance goal orientations increased the hazard probability of switching to another STEM major in the third year of college, while higher mastery-approach goal orientations decreased the hazard probability of switching to a different STEM major in the fourth year of college. Strategy use had a negligible effect on any type of major change. This study highlights the role of SRL in STEM students’ decisions to switch majors.