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College algebra is a gatekeeper course for attaining degrees and higher-paying jobs. Computer-assisted instruction (CAI) programs such as MyMathLab (MML) may help close the achievement gap among college algebra students. The purpose of this study was to conduct a meta-analysis to determine the overall effectiveness of MML among college algebra students. The data pooled from a total of (k=7) quasi-experimental primary studies that summarized the mean effect sizes using Hedge’s g in a forest plot was based on the random-effects model. The results of this meta-analysis yielded a significant effect (g=0.201,p=0.037, 95% CI [0.012 to 0.390]) favoring MML over traditional instruction among college algebra students with a low amount of heterogeneity in true outcomes detected (Q=9.392,p=0.153,tau^2=0.020,I^2=31.130%).