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This study investigates the impact of online students' health, hours of sleep, and chronic illnesses on their mental fatigue and expected grades. Data was collected from over 400 online students through a panel study using a batch of surveys. Path analysis was used to test the research-based model, and the results showed that better health conditions and longer hours of sleep lead to higher expected grades and less mental fatigue. On the other hand, chronic illnesses lead to higher mental fatigue and lower expected grades. Additionally, mental fatigue had a negative impact on expected grades.