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Guided by ecological theory, this study investigated factors of student-centered teaching (SCT). Using a large international dataset, the study examined Human Development, Power Distance, and Individualism as factors of SCT at the country-level. School-level factors included school innovativeness, teacher cooperation, and teacher-student relationship. Classroom autonomy and teachers’ self-efficacy were examined as classroom- and teacher-level factors. Combining the hierarchical linear modeling and within- and between-effects decomposition, results showed that power distance and individualism interacted in their association with SCT. School innovativeness, teacher cooperation, and teacher self-efficacy also significantly predicted SCT at both school- and teacher-levels.