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Adverse childhood experiences have been considered an important factor for a child's maladjustment. However, despite acknowledging the potential impact of neighborhood factors, how specific neighborhood adversity contexts influence children's development. This study seeks to examine a) the effects of neighborhood deprivation and threat on diverse developmental domains, and b) how the family environment may mediate the relations. These findings suggest that the family environment serves as a mechanism between adverse neighborhood environments and child development. These findings have practical implications for policy, education, and clinical work, guiding efforts to enhance the understanding of the risks and prevention strategies for children living in adverse neighborhoods.