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This systematic review aimed to identify the current state of research on using machine learning applications for predicting at-risk students (i.e. those at risk of failure or dropouts) in online learning. We adopted a quality assessment framework to appraise the studies based on necessity, reproducibility, robustness, generalizability, and interpretability. A total of 61 studies were included in the review. Findings revealed (a) a growing trend of using classical Machine Learning and Deep Learning models for predicting at-risk students and (b) a wide range in the quality appraisal results of the reviewed studies. These findings suggest a need for a common understanding of terminology and techniques, as well as the development of guidelines for consistent reporting and result comparability.