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Most approaches to sample size determination in one-way ANOVA are based on expected variation in means, but these approaches provide power only for the omnibus F test. Unfortunately, sufficient sample size for the omnibus ANOVA test does not guarantee adequate statistical power for post hoc multiple comparisons that most researchers plan to perform following a significant ANOVA (that is, not many stop after reporting a significant omnibus test). This Monte Carlo study investigated the sample sizes needed for the smallest, most-interesting post hoc mean comparison expected to be performed following a significant ANOVA. We identified sample size rules that can be applied generally for Tukey-Kramer and Games-Howell MCPs across many numbers of groups and effect size of most interest conditions.