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Recent findings suggest that COVID-19 pandemic-related sleep disturbance is common to college students but not uniformly nor universally. Given the heterogeneity of effects of the pandemic on sleep, a mixture regression model is appropriate to study college students’ sleep quality. We used the Pittsburgh Sleep Quality Index (PSQI) to assess sleep before and during the COID-19 pandemic. A number of statistical indices including a novel approach, likelihood increment percentage (LIP) and likelihood increment percentage per parameter (LIPpp), were used to determine the number of latent groups. Our results suggested a more empirically justifiable representation of two groups, “typical college sleepers” and “disordered college sleepers.” Moreover, we found several demographic and academic factors impacted the two groups differently.