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Implementing new science standards in 2012 led to a focus on inquiry science instruction to increase scientific understanding and literacy levels. Yet, a disconnect exists between K-12 science instruction and student science understanding. This paper describes the development of the research- based learning (RBL) framework to address the gap between science teaching and learning. The RBL framework aims to support student learning in science using the lens of students as researchers through scientific practices and self-regulation skills embedded within the content. The framework provides a pathway toward the vision of science instruction where students achieve deep content understanding, develop sound scientific practices, and realize lasting self-regulation skills.