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Adolescence is a critical period for intervention to promote social-emotional competencies and prevent the onset of mental health concerns which can negatively impact achievement. We developed and tested the efficacy of an 8-week social-emotional prevention intervention called Mindfulness-based Collaborative Social Reasoning (MBCSR). Using a quasi-experimental design, the study was implemented in four 6th-grade English-language arts classrooms (2 experimental-2 control) in a public middle school in the United States. The experimental group showed greater self-efficacy for using mindfulness and yoga to regulate their emotions and behaviors and lower externalizing and bullying behaviors at the post-test compared to the control group. Students in the MBCSR group reported that the program benefited their lives in multiple ways, showing a high level of program utility/usability.