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This study investigates the impact of project-based learning (PBL) on high school students’ motivation to learn genetics in a rural setting. Grounded in self-determination theory (SDT), the Meal Prepping with Genetics project aimed to enhance students’ competence, autonomy, and relatedness. Students created meal plans based on genetic research and acted as genetic counselors, applying their knowledge in real-world scenarios. Data from focus groups, reflective journals, and student artifacts were analyzed using in vivo coding to reveal increased engagement, improved attitudes towards biology, and the development of critical 21st-century skills. Despite challenges in time management and collaboration, findings suggest that PBL effectively fosters motivation and lifelong learning in STEM education, making science more relevant and encouraging students to pursue STEM careers.