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The demand for STEM professionals has been increasing in recent years. However, the number of high school students meeting postsecondary STEM readiness benchmarks has been on a steady decline. One way to raise STEM standards among high school students is through exposure to more STEM-related coursework. This study used the nationally representative High School Longitudinal Study (HSLS) dataset to explore how math and science self-efficacy relate with STEM credit accumulation and advanced math and science course-taking. We found that science self-efficacy is positively associated with STEM credit accumulation and with a higher probability of taking advanced science coursework. We explore how these outcomes differ for students with learning disabilities (SWLDs) and discuss the significance of our findings