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The COVID-19 pandemic has significantly impacted academic performance, exacerbating disparities among students from lower socioeconomic status (SES) backgrounds. This study investigates SES´s influence on scientific literacy, essential for societal engagement in an increasingly science-driven world. Using linear models and meta-analytic techniques on 2018 and 2022 PISA data across 34 OECD countries (N = 438,688), results show a positive association between SES and scientific literacy (ß = .26 CI[.22, .28]). Additionally, a notable interaction effect between SES and the PISA cycle highlights potentially exacerbated educational disparities during the pandemic (ß = .06, CI[.03,.08]). These findings deepen our understanding of educational inequalities and the COVID-19 pandemic and underscore the urgent need for targeted interventions to address SES-related disparities in scientific literacy.