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Our research integrates Computational Thinking (CT) into undergraduate biology education, focusing on non-traditional learners and enhancing DEI in the STEM workforce. Based at Medgar Evers College, we aim to boost student engagement, self-efficacy, and STEM pedagogy through CT and Scratch programming. The key research questions are: (1) How does incorporating CT and Scratch in BIO211 impact students' reflection, attitudes, and academic performance in biology? (2) To what extent does CT enhance self-efficacy? Data from this study offers a pedagogical model to equip minority-serving institutions with 21st-century skills. Our findings aim to influence policymakers, institutional leaders, students, and educators, emphasizing the advantages of interdisciplinary CT integration in fostering inclusive and effective STEM education.