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The primary objective of this research was to enhance students' comprehension of chemical equilibrium by implementing a systems thinking approach. To evaluate the effectiveness of the systems thinking approach, we compared student learning under two different instructional conditions. In the experimental group, students received instruction in a chemistry class where the curriculum was designed with a focus on systems thinking. The comparison group received identical chemistry lectures but followed a more traditional teaching approach. Both groups received instruction on chemical equilibrium, which spanned two weeks and four hours of teaching by the same instructor. The study results indicated that the systems thinking approach was superior in enhancing students' comprehension of chemical equilibrium compared to the more traditional teaching method.