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The purpose of this mixed methods case study was to explore an innovative, grant-funded program aimed at supporting preschool children affected by lead poisoning and their families in an urban community in the northeastern United States. Autoethnographic data from the initial program director and secondary data collected from children and families enrolled in the program were examined and a content analysis of program materials was conducted. Guided by pragmatism and Bronfenbrenner's bioecological model, this study provides promising evidence that intentional, sustained, collaborative efforts can benefit children affected by lead poisoning and their families, who are disproportionately from marginalized communities. This study can inform future policies and investments aimed at remedying a root cause of educational inequity: early childhood lead poisoning.