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Understanding the nature of science (NoS) is a core component of scientific literacy, but does NoS knowledge help students learn science content? We test whether NoS understanding can act as a schema to facilitate comprehension of science content. In Study 1, undergraduates watched a NoS lesson about theory change. This improved their NoS understanding but not their understanding of a subsequent psychology lesson involving theory change compared to control. In Study 2, three NoS lessons were experimentally integrated into a college psychology course, complementing content lessons in which theories change. This intervention did not improve learning, but several relationships were found between science beliefs and learning. This study contributes to a framework for the role of NoS in science education.