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Literature syntheses are essential knowledge-generation tools, particularly for topics with long research histories traversing methodological traditions. However, there is little guidance for integrating methodologically diverse findings in a mixed-methods paradigm. Through an illustrative example on racial disproportionality in special education, gifted education, and exclusionary discipline, we demonstrate a replicable process for integrating qualitative, quantitative, and mixed methodological findings. As a topic, disproportionality provided a rich literature base and an unaddressed need for guidance among interest-holders in the policy and practice spaces. As with other complex social challenges, new understandings demand approaches that center context and lived experiences without overlooking important numerical patterns. We therefore detail a literature-synthesis process for generating meta-inferences that offer new understandings on a topic.