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Adaptive learning environments (ALE) tailoring learning activities to the individual learner have been considered a promising invention for continuing education (CE). This experimental study (N = 111) evaluates the effectiveness of prior knowledge-based ALE that allow learners to skip learning contents based on their individual levels of prior knowledge. Participants using such prior knowledge-based ALE showed a higher knowledge increase during the learning period than participants in the control condition who were not allowed to skip learning contents. Further, the findings indicate that the effectiveness of prior knowledge-based ALE in supporting learning processes in CE may depend on learners’ goal orientations. These insights can help researchers, instructional designers, and educators develop and implement effective prior knowledge-based ALE for CE.