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Prior reviews have documented Latina/o students’ experiences at K-12 and undergraduate levels; yet, there is a dearth of scholarship about the adversity they face and factors that contribute to their successes within graduate contexts. Guided by a resilience framework, the purpose of this systematic review is to interrogate both vulnerabilities and protective factors that Latinas/os encounter as they navigate and progress toward degree completion. Covering scholarship from 1990-2020, we identified five vulnerabilities and five protective factors. We offer guidance on ways to expand the current knowledge base through asset-based frameworks and methodologies as well as practices for institutional agents who work closely with Latina/o students.