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This study examines the diffusion of scientific knowledge from Taiwanese higher education institutions into global technological innovations, focusing on patent citations. Analyzing 381,391 publications from 1980 to 2012, we found that only 7.84% are cited in global patents, with life sciences leading in citation rates. The U.S., Japan, and Taiwan benefit most from these citations. The impact of research policy, particularly Taiwan’s World Class University policy, was not significant in increasing patent-cited publications. Our findings suggest that enhancing the technological impact of academic research and fostering domestic and international R&D collaborations are essential for retaining economic benefits. This study contributes to understanding the science-technology link and the effectiveness of excellence initiatives in encouraging it.