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Students with a “stress-can-be-enhancing” mindset—the belief that the physiological stress response can enhance (vs. undermine) performance—have been found to have better mental health outcomes and perform better on high-stakes assessments. However, no study has examined whether teachers' stress mindsets can help them to cope with stress and teach more effectively in the classroom. Grounded in the biopsychosocial (BPS) model of challenge and threat, this study tests whether teachers’ stress mindsets predict their physiological responses and teaching effectiveness during a challenging teaching task in the laboratory (targeted n = 200). Results from six participants indicate that the novel paradigm is well-suited to test these associations. Data from the full targeted sample will be collected and analyzed before the 2025 AERA Annual Meeting.