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This study examines the impact of students’ cognitive and executive function, behavioral and emotional difficulties, and demographic variables on adolescents’ academic achievement in Latino adolescents in the Midwest. Using multi-reporter data, we separately tested associations using parent and teacher reports. Results highlight the significant roles of cognitive flexibility, emotional and behavioral difficulties, and English Language Learner status in predicting individual academic achievement variables (GPA and standardized Math and English Language Arts test scores). This study provides valuable insights into the multifaceted academic challenges, challenges, and strengths faced by this minority-minoritized population and highlights targeted areas for intervention to improve academic performance among Latino students.