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Social skills are a vital component of successfully navigating the workplace. Employers expect employees to come to the job equipped with “work ready social skills” in competitive integrated employment settings. Students with disabilities often have difficulty regulating their behavior in social settings including meeting workplace social demands. This meta-analysis synthesized single-case interventions focused on increasing workplace social skills of individuals with disabilities. The overall Tau-U effect size across the 13 included studies was .73 (SE = .09, p < .05) with a confidence interval CI95 = .55 to .90, indicating a positive impact on participant prosocial behavior. Moderator analysis suggests differences in treatment effects between study settings (i.e., school, work, combination). Implications for research and practice are discussed.