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This study investigates the moderating role of heart rate variability (HRV) and blood pressure (BP) in the relationship between race-related stress and psychological distress among undergraduates. Race-related stress has a significant impact on mental and physical health. HRV, reflecting autonomic nervous system adaptability, is linked to stress resilience. Data revealed significant racial differences in multicultural distress and racism-related stress but not in stress, anxiety, or depression. No significant racial differences were found in BP, though pulse rates varied. Findings underscore the need for targeted interventions to address racial disparities in emotional and physiological stress responses. Further research on HRV's moderating role is essential for developing effective support mechanisms.