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This study developed and validated the Comprehensive AI Integration Readiness Survey (CAIIRS) to assess higher education educators' readiness to integrate AI into their teaching practices. A nationwide survey was conducted among U.S. university educators. The CAIIRS instrument, based on literature review and expert input, was analyzed using exploratory factor analysis, revealing three main factors: AI Integration and Effectiveness in Teaching, Institutional Support for AI Integration, and Anxiety about AI Technology Use. The results showed general recognition of AI's benefits and significant anxiety among faculty and varying levels of institutional support. The study highlights the need for comprehensive professional development and strong institutional backing to facilitate effective AI integration. The CAIIRS scale is valuable for assessing faculty readiness and guiding targeted interventions.