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At a Hispanic Serving Institution (HSI) in the Southwest United States, researchers conduct a multi-year study aimed at reducing DFW rates from a General Chemistry class. Interventions of active learning and diversity-focused learning yielded a decrease from the course’s historic DFW rate of 35% to 11%, 8%, and 6% in the first three semesters of the study. A mixed-methods evaluation of the interventions resulted in findings that students perceive a disconnect between their home identity, personal identity, and their science identity. Yet, a combination of the interventions, a classroom environment conducive to peer learning, and access to instructors contribute to students’ self-efficacy. In addressing high DFW courses, researchers conclude that grades are not the only measure of success.