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This study explores the unique challenges faced by first-generation college students (FGCSs), critically evaluating dominant theoretical frameworks and proposing new models to better understand FGCSs’ experiences. A systematic literature review reveals a lack of comprehensive theories addressing FGCS complexities. Using Swanson and Chermack’s framework for theory-building in applied disciplines, key findings highlight the need for new frameworks that integrate sociopolitical awareness and familial dynamics. In this paper, I introduce several new theories based on the papers reviewed, such as the Sociopolitical Prior Knowledge Theory and the First-Generation Self-Concept Theory, aimed at providing deeper insights into the FGCS experience. These frameworks seek to improve educational strategies and policies, offering pathways for enhanced academic support and inclusion for FGCSs.