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This study investigates the impact of culturally responsive instruction on reading comprehension (RC), listening comprehension (LC), and word reading (WR) among 252 students in grades 1-3. Participants were divided into three groups: one with a generic (but still evidence-based) approach and mainstream materials, another using an evidence-based and culturally responsive approach including a critical lens and centering students' interests and cultures, and a waitlisted control group. Over 10 weeks, students received small-group instruction focused on WR and LC. GLM analyses reveal significant improvements in LC for the culturally responsive group, though neither WR nor RC showed a significant effect. The study underscores the potential to integrate cultural relevance into skill-based literacy education and advocates for a multifaceted approach.