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Intersectionality is a framework positing that complex interactions between social or demographic characteristics impact perspectives, experiences, and outcomes. Educational research has increasingly focused on the role of intersectional differences in experiences and outcomes. This literature uses mostly qualitative methods. This study uses a newer quantitative approach, Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA), for modeling and testing intersectional effects. Using data from the High School Longitudinal Study, we use MAIHDA to explore the degree of intersectional effects in STEM college readiness, and factors that contribute to intersectional differences.